An American novelist visiting Rome to promote his latest book is stalked and harassed by an obsessed fan who is committing a string of murders that appear to be tributes to his work.
Obsessed by a fleeting visual memory, English jazz pianist Marcus Daly hunts a savage, black-gloved killer through a labyrinth of nightmarish architectural spaces, promising a hyper-stylized descent into pure auditory and visual terror.
A reporter and a blind puzzle writer investigate a series of murders connected to a pharmaceutical company conducting secret genetic experiments, and find themselves targeted by the killer.